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Free Radical Recycling and Intramembrane Mobility in the Antioxidant Properties of Alpha-Tocopherol and Alpha-Tocotrienol

Abstract: d-Alpha-tocopherol (2R,4’R,8’R-Alpha-tocopherol) and d-alpha-tocotrienol are two vitamin E constituents having the same aromatic chromanol “head” but differing in their hydrocarbon “tail”: tocopherol with a saturated and toctrienol with an unsaturated isoprenoid chain. d-Alpha-tocopherol has the highest vitamin E activity, while d-alpha-tocotrienol manifests only about 30% of this activity. Since

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Comparing Palm Oil, Tocotrienol-Rich Fraction and Alpha-Tocopherol Supplementation on the Antioxidant Levels of Older Adults

Abstract: Background: Tocotrienol and tocopherol are known to prevent numerous degenerative diseases. The aim of this study is to compare the effects of tocotrienol-rich fraction (TRF) with α-tocopherol (α-TF) on the antioxidant status of healthy individuals aged between 50 and 55 years. Methods: Volunteers were divided into groups receiving placebo

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Differential Serum Responses of Tocopherols and Tocotrienols During Vitamin Supplementation in Hypercholesterolaemic Individuals Without Change in Coronary Risk Factors

Abstract: The effects of tocotrienol-rich vitamin E from palm oil on serum vitamin E concentrations, serum lipids, plasma prostaglandins and platelet function (assessed by bleeding time and aggregation) were investigated in 44 subjects (23 males, 21 females) with hypercholesterolaemia. Following a 6-week run-in period, subjects were randomized for 20 weeks

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Dose-dependednt suppression of serum cholesterol by tocotrienol-rich fraction (TRF25) of rice bran in hypercholesterolemic humans

Abstract: Tocotrienols are effective in lowering serum total and LDL-cholesterol levels by inhibiting the hepatic enzymic activity of beta-hydroxy-beta-methylglutaryl coenzymeA (HMG-CoA) reductase through the post-transcriptional mechanism. alpha-Tocopherol, however, has an opposite effect (induces) on this enzyme activity. Since tocotrienols are also converted to tocopherols in vivo, it is necessary not

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Effect of Mixed-Tocotrienols in Hypercholesterolemic Subjects

Abstract: Background: Studies on the cholesterol lowering activity of tocotrienols have yielded mixed results, with some showing cholesterol lowering effect while some showing no activity. Aim: A randomized, double-blind, parallel group study was conducted to investigate the cholesterol lowering activity of tocotrienols. Methods: Thirty-two hypercholesterolemic subjects were randomly assigned to

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Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers

Abstract: Background/Objectives: Vitamin E is an essential fat-soluble vitamin that has been shown to induce favorable effects on animal and human immune systems. The objective of this study was to assess the effects of tocotrienol-rich fraction (TRF) supplementation on immune response following tetanus toxoid (TT) vaccine challenge in healthy female

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